The Human Endometrial Response to Several Synthetic Progestins

Several synthetic progestins disrupt the glial cell specific-brain aromatase expression in developing zebra fish.

The effects of some progestins on fish reproduction have been recently reported revealing the hazard of this class of steroidal pharmaceuticals. However, their effects at the central nervous system level have been poorly studied until now. Notwithstanding, progesterone, although still widely considered primarily a sex hormone, is an important agent affecting many central nervous system function...

Growth inhibition by progestins in a human endometrial cancer cell line with estrogen-independent progesterone receptors.

The presence of estrogen-independent progesterone receptors (PgR) was demonstrated in a subline of a human endometrial cancer cell line, Ishikawa cells, although the original Ishikawa cells contained estrogen-inducible PgR. Scatchard plot analysis of cytoplasmic binding data in our subline (IK-90) revealed a high affinity binding site for R5020 (Kd, 1.0 nM) with maximum binding sites of 158 fmo...

Transforming growth factor gene expression in human endometrial adenocarcinoma cells: regulation by progestins.

In an attempt to understand the antiproliferative effects of progestins in endometrial cancer, we have examined the effects of the potent progestin, medroxyprogesterone acetate (MPA), on the cell proliferation and the expression of transforming growth factor (TGF) alpha and beta genes in human endometrial adenocarcinoma cell lines. The two cell lines used were Ishikawa, var 1, and HEC-50. In ad...

Human Response to Several Impact Acceleration Orientations and Patterns.

There is considerable indicatiou that the head wl present a problem in tolerance wo impaot accelration, patterns as more severe expoures are invetatigated. There is. however. no basis in theso results for a fore-mstof any probatble or aluolute uzjus level.Preliminary results af a mnathemnatical analysts have beem presented, and the ttends indicatethat it h desirable to attenuate high.frrqmeney ...

Effect of Adding Human Chorionic Gonadotropin to The Endometrial Preparation Protocol in Frozen Embryo Transfer Cycles